Endocrine Abstracts

Introduction: Hypocalcaemia is a rare and potentially reversible cause of cardiomyopathy. Restoration to normal serum calcium levels usually leads to rapid improvement of cardiac function.Case report: A 42-year-old woman with a history of total thyroidectomy, due to large nodular goiter in 2016, and acute pos-operative hypoparathyroidism, assumed to be transient, with no supplementation since early 2017. In September 2018 she was admitted due to acute ca...

Introduction: Vitamin D is a hormone that acts through the Vitamin D receptor (VDR) not only on the skeletal system but on a great number of target tissues, including thyroid gland. In recent years the association of vitamin D with autoimmune thyroid diseases (AITD), has been suggested.VDR gene polymorphisms had been associated with an increased risk of AITD. In addition a recent meta-analysis showed that AITD patients had lower level of 25-hydroxyvitami...

Introduction: Glycemic variability (GV) is emerging as a measure of glycemic control in type 1 diabetic patients (T1DM) given that it provides an integrated picture of postprandial hyperglycemia and hypoglycemic episodes and is associated with diabetic complications and mortality. However, little is known about the best way to address this problem in clinical practice.Aim: To characterize GV in T1DM patients followed in our center and to identify clinica...

Introduction: Clinical trial data demonstrate improved glycemic control in individuals with type 1 diabetes (T1D),especially, reduction of time in hypoglycaemia with flash glucose monitoring (FGM);however real-life conditions can modify this scenario.Aim: To examine real world use and glycemic control following a standardized initiation process of FGM.Methods: Individuals aged 18 years or older with T1D were prospectively recruited...

IntroductionSimultaneous pancreas-kidney transplantation (PKT) has a beneficial effect on the evolution of chronic complications in type 1 diabetic (T1D) patients with terminal chronic kidney disease (CKD). However, the CKD-mineral and bone disorder (CKD-MBD) remains a frequent complication. There are a few studies addressing the long-term evolution of bone mineral density (BMD) in these patients.AimTo charac...

IntroductionHypoparathyroidism (hypoPT) is one of the most complications after thyroid surgery, usually as transient hypocalcemia. Permanent hypoPT due to permanent parathyoid lesion, despite being less frequent, is associated to long term consequences for both objective and subjective well-being and should be prevented. Identifying predictive factors associated with post- thyroidectomy hypoPT is thereby crucial.Aim<p class="ab...

Introduction: In singleton pregnancies, gestational diabetes mellitus (GDM) results in an increased risk for maternal and neonatal complications. In twin pregnancies, however, the effect of GDM on maternal and neonatal complications appears to be different in comparison to singletons. The few studies that investigated the consequences of GDM in twin pregnancies are small and present conficting evidence, with some finding no difference in perinatal outcomes between GDM and non-...

Introduction: Monogenic forms of diabetes that develop with autosomal dominant inheritance are classically aggregated in the maturity-onset diabetes of the young (MODY) categories. Despite increasing awareness, its true prevalence remains largely underestimated.Aim: o evaluate the clinical and molecular characteristics of patients with MODY.Methodology: This single-center retrospective cohort study enrolled patients with positive g...

Introduction: Simultaneous pancreas-kidney transplantation remains the best treatment option in type 1 diabetic patients with chronic kidney failure, providing a euglycemic state associated with an improvement on diabetic chronic complications. However, there are only a few studies addressing the potential ischemic deterioration of peripheral arterial disease, due to blood diverting from the iliac artery to the kidney graft.Aim: Evaluate diabetic foot le...